Purified anti-mouse/human Helios 137202 from BioLegend

Product Specs
ItemPurified anti-mouse/human Helios
CompanyBioLegend
Price Pricing Info Supplier Page View Company Product Page
Catalog Number137202
IsotypeIgG
ApplicationsIntracellular Staining for Flow Cytometry (ICFC), Immunoprecipitation (IP)
Conjugate/TagUnconjugated
ReactivityMouse, Human
NCBI Gene AliasesHELIOS, Helios, ZNF1A2, A730095J18Rik, ANF1A2, Znfn1a2, Zfpn1a2, ZNFN1A2
Quantity100 µg
HostArmenian Hamster
Clone22F6
Antibody TypePrimary
NCBI Full Gene NameIKAROS family zinc finger 2
Concentration0.50 mg/mL
FormatPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
ImmunogenHelios peptide (aa 51-107)
ClonalityMonoclonal
TargetHelios

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BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and SafetyCancer DiscoveryJanuary 9, 2023Nicholas A. Vitanza, Ashley L. Wilson, Wenjun Huang, Kristy Seidel, Christopher Brown, Joshua A. Gustafson, Jason K. Yokoyama, Adam J. Johnson, Blake A. Baxter, Ryan W. Koning, et al.(BD Pharmingen, cat. #550405, BNI3), CCR7 (BioLegend, cat. #353202, G043H7), HELIOS (BioLegend, cat. #137202, 22F6), TBET (Thermo Fisher, 14-5825-82, eBio4B10), CCR5 (Bio-Rad, cat. #MCA2175GA, HEK/1/85a), Eomes

(2) The transcription factor IRF2 drives interferon-mediated CD8(+) T cell exhaustion to restrict anti-tumor immunityImmunityDecember 13, 2022Lukhele S, Rabbo DA, Guo M, Shen J, Elsaesser HJ, Quevedo R, Carew M, Gadalla R, Snell LM, Mahesh L, et al.(Clone B56),BD Biosciences,Cat#550609; RRID: AB_393778 173Yb-anti-Helios (Clone 22F6),Biolegend,Cat#137202; RRID: AB_10900638 174Yb-anti-CD11c (Clone N418),Biolegend,Cat#117301; RRID: AB_313770 174Yb-anti-Lag3

(3) Mass cytometry immunostaining protocol for multiplexing clinical samplesSTAR protocolsSeptember 16, 2022Gadalla R, Boukhaled GM, Brooks DG, Wang BX.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, CD16,Fluidigm,3209002B CD80,BD Biosciences,55568 CD45RA,BioLegend,304143 Helios,BioLegend,137202 Ki67,BioLegend,350523 T-bet,Fluidigm,3161014B CD45,Fluidigm,3089003B CD45,Fluidigm,3198001B CD28,BioLegend,302937 CD137,BioLegend,309802 CD86,BioLegend,555655 TIM3,BioLegend,345019 PKR,Novus

(4) A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infectionCell ReportsMay 17, 2022Elizabeth E. McCarthy, Pamela M. Odorizzi, Emma Lutz, Carolyn P. Smullin, Iliana Tenvooren, Mars Stone, Graham Simmons, Peter W. Hunt, Margaret E. Feeney, Philip J. Norris, et al.RRID:AB_2661806 Yb171-CXCR5 (clone RF8B2),Fluidigm,Cat#3171014B; RRID:AB_2858239 Yb172-Helios (clone 22F6),BioLegend,Cat#137202; RRID:AB_10900638 Yb173-Granzyme B (clone GB11),BioRad,Cat#MCA2120; RRID:AB_2114582 Biological samples,, Cryopreserved

(5) Microbial exposure during early human development primes fetal immune cellsCellJune 24, 2021Mishra A, Lai GC, Yao LJ, Aung TT, Shental N, Rotter-Maskowitz A, Shepherdson E, Singh GSN, Pai R, Shanti A, et al.157,BioLegend,"Cat# 145202, RRID: AB_2561841" Helios (clone 22F6) metal channel 174,BioLegend,"Cat# 137202, RRID: AB_10900638" TGF-β1 (LAP) (clone TW4-2F8) metal channel 153,BioLegend,"Cat# 349602, RRID: AB_10645476" IL-10

(6) Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infectionCell reports. MedicineMay 18, 2021Rouers A, Chng MHY, Lee B, Rajapakse MP, Kaur K, Toh YX, Sathiakumar D, Loy T, Thein TL, Lim VWX, et al.(ThermoFisher),14-4877-82 Anti-human-RORγt 168Er (600214),Fluidigm,3168018B Anti-human-Helios purified (22F6),Biolegend,137202 Anti-human-BCL-2 purified (100),Biolegend,658702 Anti-human-TCR Vδ2 purified (B6),Biolegend,331402 Anti-human-TCR

(7) DNA hypomethylating agents increase activation and cytolytic activity of CD8⁺ T cellsMolecular cellApril 1, 2021Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, et al.

(8) Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfectionImmunityMarch 9, 2021Xu W, Snell LM, Guo M, Boukhaled G, Macleod BL, Li M, Tullius MV, Guidos CJ, Tsao MS, Divangahi M, et al.BD,Cat#550609; RRID: AB_393778 173Yb-anti-Helios (Clone 22F6),Purified antibody from BioLegend,Cat#137202; RRID: AB_10900638 174Yb-anti-CD11c (Clone N418),Purified antibody from BioLegend,Cat#117301; RRID:

(9) Human Tumor-Infiltrating MAIT Cells Display Hallmarks of Bacterial Antigen Recognition in Colorectal CancerCell reports. MedicineJune 23, 2020Li S, Simoni Y, Becht E, Loh CY, Li N, Lachance D, Koo SL, Lim TP, Tan EKW, Mathew R, et al.(clone GHI/75),Biolegend,"Cat# 333702, RRID:AB_1089089" 169 - HELIOS (clone 22F6),Biolegend,"Cat# 137202, RRID:AB_10900638" 171 - VD2 (clone B6),Biolegend,"Cat# 331402, RRID:AB_1089226" 172 - VG9 (clone

(10) Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell FatesImmunityDecember 17, 2019Chng MHY, Lim MQ, Rouers A, Becht E, Lee B, MacAry PA, Lye DC, Leo YS, Chen J, Fink K, et al.

(11) Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell StatesImmunityApril 16, 2019Wei SC, Sharma R, Anang NAS, Levine JH, Zhao Y, Mancuso JJ, Setty M, Sharma P, Wang J, Pe'er D, et al.Clone:L50-823 anti-H-2K b/H-2D b 196Pt,Biolegend,Cat #:114602; Clone:28-8-6 anti-Helios 172Yb,Biolegend,Cat #:137202; Clone:22F6 anti-ICOS 155Gd,eBioscience,Cat #:14-9942-85; Clone:7E.17G9 anti-Ikaros 144Nd,Biolegend,Cat

(12) Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T CellsImmunityMay 15, 2018Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, et al.Cat#sc-56125 "Anti-Granzyme M, clone 4B2G4",Bovenschen lab,n/a "Anti-Helios, clone 22F6",Biolegend,RRID:AB_10900638 Cat#137202 "Anti-HLA-DR, clone L243",Biolegend,RRID:AB_314680 Cat#307602 Anti-ICOS clone C398.4A,Biolegend,RRID:AB_416326

(13) Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3⁺ Treg cellsJournal of immunological methodsDecember 1, 2014Verhagen J, Wraith DC.

(14) Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and miceImmunology and cell biologySeptember 1, 2014Bedke T, Iannitti RG, De Luca A, Giovannini G, Fallarino F, Berges C, Latgé JP, Einsele H, Romani L, Topp MS.

(15) Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitisAmerican journal of physiology. Gastrointestinal and liver physiologyJuly 15, 2014Liu Y, Tran DQ, Fatheree NY, Marc Rhoads J.

(16) Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacityPloS oneJanuary 1, 2014Angin M, Klarenbeek PL, King M, Sharma SM, Moodley ES, Rezai A, Piechocka-Trocha A, Toth I, Chan AT, Goulder PJ, et al.

(17) Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cellsClinical immunology (Orlando, Fla.)November 1, 2012Stone B, Rieck M, Rawlings CA, Kas A, Shendure J, Jones H, Buckner JH.

(18) Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cellsProceedings of the National Academy of Sciences of the United States of AmericaOctober 2, 2012Vaeth M, Schliesser U, Müller G, Reissig S, Satoh K, Tuettenberg A, Jonuleit H, Waisman A, Müller MR, Serfling E, et al.

(19) Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cellsJournal of immunology (Baltimore, Md. : 1950)April 1, 2010Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM.

(20) Early diagnosis of crepitant gangrene caused by Bacteroides melaninogenicusPlastic and reconstructive surgeryAugust 1, 1978V L Lewis, M B Myers, B H Griffith

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Purified anti-mouse/human Helios from BioLegend

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Purified anti-mouse/human Helios from BioLegend

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